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Markku Heikinheimo Selected Research

GATA4 Transcription Factor

7/2018Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells.
3/2017Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis.
1/2012Transcription factor GATA-4 is abundantly expressed in childhood but not in adult liver tumors.
9/2010GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis.
7/2009Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1.
10/2004Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4.

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Markku Heikinheimo Research Topics

Disease

35Neoplasms (Cancer)
01/2022 - 01/2002
13Granulosa Cell Tumor
04/2020 - 12/2005
8Carcinogenesis
02/2016 - 09/2003
6Hepatoblastoma
01/2021 - 04/2002
5Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
03/2010 - 01/2002
3Biliary Atresia
01/2022 - 01/2018
3Fibrosis (Cirrhosis)
06/2021 - 06/2014
3Hyperplasia
05/2021 - 01/2017
3Hepatocellular Carcinoma (Hepatoma)
10/2020 - 01/2006
3Ovarian Neoplasms (Ovarian Cancer)
01/2017 - 11/2011
2Inflammation (Inflammations)
05/2021 - 07/2009
2Tyrosinemias (Tyrosinemia)
10/2020 - 01/2006
2Adenoma (Adenomas)
02/2016 - 04/2005
2Adrenocortical Carcinoma
08/2013 - 04/2005
2Carcinoma (Carcinomatosis)
08/2013 - 12/2011
2Teratoma (Teratoid Tumor)
08/2010 - 10/2003
2Germinoma
08/2009 - 01/2008
2Endodermal Sinus Tumor (Endodermal Sinus Tumors)
10/2003 - 01/2002
1Jaundice (Icterus)
01/2022
1Hyperoxia
10/2021
1Liver Cirrhosis (Hepatic Cirrhosis)
06/2021
1Hypertension (High Blood Pressure)
10/2020
1Osteoporosis
10/2020
1Metabolic Bone Diseases (Osteopenia)
10/2020
1Malaria
01/2020
1Short Bowel Syndrome
01/2020
1Metaplasia
01/2018
1Liver Neoplasms (Liver Cancer)
03/2017
1B-Cell Lymphoma (Lymphoma, B Cell)
03/2017
1Endometriosis
01/2017
1Ovarian Epithelial Carcinoma
01/2017
1Choristoma (Ectopic Tissue)
01/2017
1Pituitary Neoplasms (Pituitary Adenoma)
02/2016
1Parathyroid Neoplasms (Parathyroid Neoplasm)
02/2016
1Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor)
02/2016
1Infertility (Sterility)
01/2015
1Pulmonary Valve Insufficiency (Insufficiency, Pulmonary Valve)
06/2014
1Tetralogy of Fallot (Fallot Tetralogy)
06/2014

Drug/Important Bio-Agent (IBA)

14Proteins (Proteins, Gene)FDA Link
01/2022 - 05/2004
11Messenger RNA (mRNA)IBA
06/2021 - 02/2001
9Transcription Factors (Transcription Factor)IBA
07/2018 - 04/2005
6Hormones (Hormone)IBA
04/2020 - 12/2005
6GATA4 Transcription FactorIBA
07/2018 - 10/2004
4Pharmaceutical PreparationsIBA
01/2020 - 01/2006
4GATA6 Transcription FactorIBA
01/2018 - 10/2003
4GATA Transcription FactorsIBA
02/2016 - 02/2007
4Inhibins (Inhibin)IBA
08/2013 - 12/2005
4GonadotropinsIBA
04/2007 - 09/2003
3CytokinesIBA
06/2021 - 09/2010
3alpha-Fetoproteins (alpha-Fetoprotein)IBA
10/2020 - 01/2002
3SteroidsIBA
01/2017 - 09/2005
3Tumor Biomarkers (Tumor Markers)IBA
01/2017 - 01/2002
3Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric
01/2008 - 01/2002
3LH Receptors (LH Receptor)IBA
04/2007 - 09/2003
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2021 - 09/2010
2nitisinone (Orfadin)FDA Link
10/2020 - 01/2006
2Estradiol (Delestrogen)FDA LinkGeneric
04/2020 - 08/2009
2RNA (Ribonucleic Acid)IBA
04/2020 - 07/2018
2CarbohydratesIBA
01/2017 - 01/2002
2AntigensIBA
01/2017 - 01/2002
2inhibin BIBA
01/2017 - 10/2015
2Protein CIBA
09/2012 - 01/2002
2Estrogens (Estrogen)FDA Link
06/2012 - 12/2005
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2011 - 01/2011
2Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
12/2011 - 01/2011
2Steroidogenic Factor 1IBA
03/2010 - 04/2005
2Tumor Viral Antigens (Large T Antigen)IBA
04/2007 - 10/2004
1Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA
01/2022
1Perilipin-4IBA
01/2022
1secretin receptorIBA
01/2022
1Small Cytoplasmic RNAIBA
10/2021
1Interleukin-8 (Interleukin 8)IBA
06/2021
1Laminin (Merosin)IBA
06/2021
1IntegrinsIBA
06/2021
1Caveolin 1IBA
05/2021
1Transforming Growth Factors (Transforming Growth Factor)IBA
05/2021
1Neuropilin-2IBA
01/2021
1Glycoproteins (Glycoprotein)IBA
01/2021
1NeuropilinsIBA
01/2021
1Aromatase (CYP19)IBA
04/2020
1Biomarkers (Surrogate Marker)IBA
04/2020
1Chloroquine (Aralen)FDA LinkGeneric
01/2020
1Doxorubicin (Adriamycin)FDA LinkGeneric
03/2017
1Dasatinib (BMS 354825)FDA Link
01/2017
1MTOR InhibitorsIBA
01/2017
1Paclitaxel (Taxol)FDA LinkGeneric
01/2017
1Capsules (Microcapsules)IBA
01/2017
1TamoxifenFDA LinkGeneric
01/2017
1TNF-Related Apoptosis-Inducing LigandIBA
09/2016
1CateninsIBA
02/2016
1Oral ContraceptivesIBA
01/2015
1GadoliniumIBA
06/2014
1Brain Natriuretic Peptide (Natrecor)FDA Link
06/2014
1Collagen Type III (Type III Collagen)IBA
06/2014
1pro-brain natriuretic peptide (1-76)IBA
06/2014

Therapy/Procedure

6Drug Therapy (Chemotherapy)
01/2020 - 04/2002
6Castration
01/2017 - 09/2003
3Therapeutics
04/2020 - 01/2002
3Liver Transplantation
08/2010 - 04/2002
2Parenteral Nutrition
05/2021 - 01/2020